Morrell S, Tallino L, Lei Y, Burkhead JL
Case reports and small observational studies from dermatology centers suggest that patients using semaglutide for weight management experienced fewer HS lesions and shorter healing times
CJC-1295: Subcutaneous injection
Menegale F, Manica M, Zardini A, Guzzetta G, Marziano V, d'Andrea V, et al
This translational failure is likely multifactorial, stemming from CsAs indirect mechanism, which may permit pore opening under high stimulation, confounding off-target effects like calcineurin inhibition, and the reality that, much like the challenge facing anti-apoptotic strategies, MIRI activates multiple redundant cell death programs (such as the increasingly recognized ferroptosis), making the inhibition of mPTP-mediated necrosis alone likely insufficient to salvage the myocardium (Zhou et al., 2020)